Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds

I.A. Farbun; V.A. Trykhlib

doi:10.15330/pcss.21.4.707-713

Authors

I.A. Farbun Institute for Sorption and Problems of Endoecology
V.A. Trykhlib Institute for Sorption and Problems of Endoecology

DOI:

https://doi.org/10.15330/pcss.21.4.707-713

Keywords:

uremic toxins adsorption, amino acids adsorption, carbon adsorbents, tryptophan, arginine, indole, creatinine, vitamine B12

Abstract

The paper investigates the regulation of the hydrophobicity of KARBON™ carbon adsorbents by restoring its surface during heat treatment in argon and hydrogen, as well as oxidizing it with nitric acid. The sorption capacity of KARBON™ with respect to the tryptophan, arginine, indole, creatinine and vitamin B₁₂as biologically active organic compounds of different molecular weight was studied. It was determined that the adsorption capacity of KARBON™ samples with respect to all the studied substances changes as follows: Ind>Cr>Trp>Arg>B₁₂. It has been shown that the sorption capacity of argon-treated KARBON™ adsorbent at pH=7.5 is 2.6; 2.7 and 0.09 mmol/g in relation to tryptophan, creatinine and vitamin B₁₂, respectively. The adsorption capacity of these compounds is almost unchanged when the acidity changes from 7.5 to 2.0. The results obtained allows the use of KARBON™ adsorbent as a therapeutic and/or prophylactic agent for oral administration in chronic kidney and liver diseases, as well as a hemosorbent for the purification of blood outside the human body.

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