Геополімер для медичного застосування: огляд
DOI:
https://doi.org/10.15330/pcss.25.3.626-638Ключові слова:
антибактеріальна дія, біокераміка, доставка ліків, геополімер, медицинаАнотація
Матеріали для медичного застосування зазвичай формують з металу, кераміки та полімеру. Кожен матеріал має свої обмеження, такі як корозія металу, крихкість кераміки та висока температура полімеру. Щоб усунути їхні слабкості, рекомендується комбінувати один або кілька відповідних матеріалів, які називають композитними. Одним із нових композиційних матеріалів, які можна використовувати в медичних цілях – це геополімер, який є неорганічним полімерним матеріалом, що складається з алюмосилікатних джерел, таких як метакаолін і золь-гелевий синтезований матеріал та активатора лугу, що складається із сильного гідроксиду лугу та розчину силікату натрію. У цьому оглядовому дослідженні розглянуто сировину, лужні активатори та домішки для геополімерів, а також застосування матеріалу на основі геополімерів у медичних цілях. Також обговорюються перспективи та проблеми геополімерів для медицини. Регульована міцність і пористість роблять цей матеріал універсальним для покриття субстратів, щоб стати матеріалом кісткового каркасу. Проте залишається занепокоєння щодо вимивання та високої лужності геополімерів. Це можна покращити, зменшивши молярність гідроксиду натрію та змішавши геополімер із сполуками, щоб уловити шкідливий агент фільтрації всередині та вивчити різні розчини для активації геополімеру.
Посилання
J. Zhao, et al., Eco-friendly geopolymer materials: A review of performance improvement, potential application and sustainability assessment. Journal of Cleaner Production, 307, 127085 (2021); https://doi.org/10.1016/j.jclepro.2021.127085.
B. Bakhtyar, T. Kacemi, and M.A. Nawaz, A review on carbon emissions in Malaysian cement industry. International Journal of Energy Economics and Policy, 7(3), 282 (2017).
M. Grant Norton, and J.L. Provis, 1000 at 1000: Geopolymer technology—the current state of the art. Journal of Materials Science, 55(28), 13487 (2020); https://doi.org/10.1007/s10853-020-04990-z.
G. Roviello, et al., Hybrid geopolymers from fly ash and polysiloxanes. Molecules, 24(19), 3510 (2019); https://doi.org/10.3390/molecules24193510.
L. Ricciotti, et al., Geopolymer-based hybrid foams: Lightweight materials from a sustainable production process. Journal of cleaner production, 250, 119588 (2020); https://doi.org/10.1016/j.jclepro.2019.119588.
G. Roviello, et al., Hybrid geopolymeric foams for the removal of metallic ions from aqueous waste solutions. Materials, 12(24), 4091 (2019); https://doi.org/10.3390/ma12244091.
L. Ricciotti, et al., Development of Geopolymer-Based Materials with Ceramic Waste for Artistic and Restoration Applications. Materials, 15(23); 8600 (2022); https://doi.org/10.3390/ma15238600.
D.-W. Zhang, D.-M. Wang, and F.-Z. Xie, Microrheology of fresh geopolymer pastes with different NaOH amounts at room temperature. Construction and Building Materials, 207, 284 (2019); https://doi.org/10.1016/j.conbuildmat.2019.02.149.
D.-W. Zhang, et al., Rheology, agglomerate structure, and particle shape of fresh geopolymer pastes with different NaOH activators content. Construction and Building Materials, 187, 674 (2018); https://doi.org/10.1016/j.conbuildmat.2018.07.205.
M.S. Siti Salwa, et al., Review on Current Geopolymer as a Coating Material. Australian Journal of Basic and Applied Sciences, 7(5), 246 (2013).
A. El Khomsi, et al., Geopolymer Composite Coatings Based on Moroccan Clay and Sands for Restoration Application. Frontiers in Chemical Engineering, 3, (2021); https://doi.org/10.3389/fceng.2021.667982.
P. Bhardwaj, Optimization studies and characterization of advanced geopolymer coatings for the fabrication of mild steel substrate by spin coating technique. Indian Journal of Chemical Technology (IJCT), 28(1), (2021); https://doi.org/10.56042/ijct.v28i1.31721.
J. Novotný, et al., Manufacture and Characterization of Geopolymer Coatings Deposited from Suspensions on Aluminium Substrates. Coatings, 12(11), 1695 (2022); https://doi.org/10.3390/coatings12111695.
L. Biondi, et al., Ambient Cured Fly Ash Geopolymer Coatings for Concrete. Materials, 12(6), 923 (2019); https://doi.org/10.3390/ma12060923.
R. Petrescu, et al., News in bone modeling for customized hybrid biological prostheses development. OnLine J. Biol. Sci, 21, 285 (2021); https://doi.org/10.3844/ojbsci.2021.285.316.
S. Mu, et al., Property and microstructure of aluminosilicate inorganic coating for concrete: Role of water to solid ratio. Construction and Building Materials, 148, 846 (2017); https://doi.org/10.1016/j.conbuildmat.2017.05.070.
M. Criado, et al., Alkali activated fly ash: effect of admixtures on paste rheology. Rheologica Acta, 48(4), 447 (2009); https://doi.org/10.1007/s00397-008-0345-5.
H. Mundra, et al., Rheological properties of Class F fly-ash based alkali-activated materials (AAMs) for oil and gas well cementing applications. CEMENT, 12, 100068 (2023); https://doi.org/10.1016/j.cement.2023.100068.
X. Dai, et al., Rheology and microstructure of alkali-activated slag cements produced with silica fume activator. Cement and Concrete Composites, 125, 104303 (2009); https://doi.org/10.1016/j.cemconcomp.2021.104303.
Y. Faza, et al., Synthesis of Porous Metakaolin Geopolymer as Bone Substitute Materials. Key Engineering Materials, 829, 182 (2020); https://doi.org/10.4028/www.scientific.net/KEM.829.182.
E. Baranowska-Wójcik, et al., Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review. Biological Trace Element Research, 193(1), 118 (2020); https://doi.org/10.1007/s12011-019-01706-6.
D. Askri, et al., Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics. International Journal of Molecular Sciences, 20(20), 5186 (2019); https://doi.org/10.3390%2Fijms20205186.
A. Harmaji, O.D. Putri, and B. Sunendar, Mechanical And Microstructural Assessment Of Synthetic Aluminosilicate Based Geopolymer Dental Material. Fullerene Journal of Chemistry, 7(2), 52 (2023); https://doi.org/10.37033/fjc.v7i2.425.
Y.-S. Wang, J.L. Provis, and J.-G. Dai, Role of soluble aluminum species in the activating solution for synthesis of silico-aluminophosphate geopolymers. Cement and Concrete Composites, 93, 186 (2018); https://doi.org/10.1016/j.cemconcomp.2018.07.011.
F.A. Shilar, S.V. Ganachari, and V.B. Patil, Advancement of nano-based construction materials-A review. Construction and Building Materials, 359, 129535 (2022); https://doi.org/10.1016/j.conbuildmat.2022.129535.
Y. Wang, et al., Comparison of Effects of Sodium Bicarbonate and Sodium Carbonate on the Hydration and Properties of Portland Cement Paste. Materials, 12(7); 1033 (2019); https://doi.org/10.3390/ma12071033.
E. Adesanya, et al., One-part geopolymer cement from slag and pretreated paper sludge. Journal of Cleaner Production, 185, 168 (2018); https://doi.org/10.1016/j.jclepro.2018.03.007.
O. Wan-En, et al., The Effect of Sodium Carbonate on the Fresh and Hardened Properties of Fly Ash-Based One-Part Geopolymer. IOP Conference Series: Materials Science and Engineering, 864 (1), 012197 (2020); https://doi.org/10.1088/1757-899X/864/1/012197.
S. Ouyang, et al., Experimental study of one-part geopolymer using different alkali sources. Journal of Physics: Conference Series, 1605(1), 012155 (2020); https://doi.org/10.1088/1742-6596/1605/1/012155.
L.Y. Ming, et al., Characteristic of One-Part Geopolymer as Building Materials, in Sustainable Waste Utilization in Bricks, Concrete, and Cementitious Materials: Characteristics, Properties, Performance, and Applications, A. Abdul Kadir, N. Amira Sarani, and S. Shahidan, Editors. 2021, Springer Singapore: Singapore. 97 (2021); https://doi.org/10.1007/978-981-33-4918-6_6.
W. Teo, et al., Experimental Investigation on Ambient-Cured One-Part Alkali-Activated Binders Using Combined High-Calcium Fly Ash (HCFA) and Ground Granulated Blast Furnace Slag (GGBS). Materials, 15(4), 1612 (2022); https://doi.org/10.3390/ma15041612.
L.N. Assi, E. Deaver, and P. Ziehl, Using sucrose for improvement of initial and final setting times of silica fume-based activating solution of fly ash geopolymer concrete. Construction and Building Materials, 191, 47 (2018); https://doi.org/10.1016/j.conbuildmat.2018.09.199.
P. Risdanareni, J.J. Ekaputri, and Triwulan, The Influence of Alkali Activator Concentration to Mechanical Properties of Geopolymer Concrete with Trass as a Filler. Materials Science Forum, 803, 125 (2015); http://dx.doi.org/10.4028/www.scientific.net/MSF.803.125.
J. Kohout, and P. Koutník, Effect of Filler Type on the Thermo-Mechanical Properties of Metakaolinite-Based Geopolymer Composites. Materials, 13(10), 2395 (2020); https://doi.org/10.3390/ma13102395.
H. Yangthong, et al., Novel natural rubber composites with geopolymer filler. Advances in Polymer Technology, 37(7), 2651 (2018); https://doi.org/10.1002/adv.21940.
M.F.A. Hashim, et al., Effect of Geopolymer filler in Glass Reinforced Epoxy (GRE) Pipe for Piping Application: Mechanical Properties. IOP Conference Series: Materials Science and Engineering, 133(1); 012044 (2016); http://dx.doi.org/10.1088/1757-899X/133/1/012044.
M.F.A. Hashim, et al., Interaction of Geopolymer Filler and Alkali Molarity Concentration towards the Fire Properties of Glass-Reinforced Epoxy Composites Fabricated Using Filament Winding Technique. Materials, 15(18); 6495 (2022) https://doi.org/10.3390/ma15186495.
R. Gulati, S. Sharma, and R.K. Sharma, Antimicrobial textile: recent developments and functional perspective. Polym Bull (Berl), 79(8), 5747 (2022); https://doi.org/10.1007/s00289-021-03826-3.
H.A. Abdel-Gawwad, S.A. Mohamed, and M.S. Mohammed, Recycling of slag and lead-bearing sludge in the cleaner production of alkali activated cement with high performance and microbial resistivity. Journal of Cleaner Production, 220, 568 (2019); https://doi.org/10.1016/j.jclepro.2019.02.144.
P. Sikora, et al., Antimicrobial activity of Al2O3, CuO, Fe3O4, and ZnO nanoparticles in scope of their further application in cement-based building materials. Nanomaterials, 8(4), 212 (2018); https://doi.org/10.3390%2Fnano8040212.
M.H. Toodehzaeim, et al., The effect of CuO nanoparticles on antimicrobial effects and shear bond strength of orthodontic adhesives. Journal of Dentistry, 19(1), 1 (2018).
M.S. Dahiya, V.K. Tomer, and S. Duhan, Bioactive glass/glass ceramics for dental applications, in Applications of nanocomposite materials in dentistry. Elsevier. 1 (2019); https://doi.org/10.3390/ijms20235960.
R.M.-d .Gutiérrez, et al., Evaluation of the Antibacterial Activity of a Geopolymer Mortar Based on Metakaolin Supplemented with TiO2 and CuO Particles Using Glass Waste as Fine Aggregate. Coatings, 10(2) 157 (2020); https://doi.org/10.3390/coatings10020157.
A. Rondinella, et al., Mechanical and antibacterial behavior of multilayered geopolymer coatings on Ti6Al4V alloys. Journal of Materials Science, 57(39), 18578(2022); https://doi.org/10.1007/s10853-022-07767-8.
A. Kędziora, et al., Comparison of Antibacterial Mode of Action of Silver Ions and Silver Nanoformulations With Different Physico-Chemical Properties: Experimental and Computational Studies. Frontiers in Microbiology, 12, (2021); https://doi.org/10.3389/fmicb.2021.659614.
J.C. Mather, et al., Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes. Dalton Transactions, 51(32), 12056 (2022); https://doi.org/10.1039/D2DT01657E.
D. Adak, et al., Anti-microbial efficiency of nano silver–silica modified geopolymer mortar for eco-friendly green construction technology. RSC Advances, 5(79), 64037(2015); https://doi.org/10.1039/C5RA12776A.
J.-C. Rubio-Avalos, Antibacterial Metakaolin-Based Geopolymer Cement. in Calcined Clays for Sustainable Concrete. Dordrecht: Springer Netherlands. (2018); http://dx.doi.org/10.1007/978-94-024-1207-9_64.
J. Forsgren, et al., Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. PLoS One, 6(3), e17759 (2011); https://doi.org/10.1371/journal.pone.0017759.
B. Cai, H. Engqvist, and S. Bredenberg, Evaluation of the resistance of a geopolymer-based drug delivery system to tampering. International Journal of Pharmaceutics, 465(1), 169(2014); https://doi.org/10.1016/j.ijpharm.2014.02.029.
E. Jämstorp, M. Strømme, and S. Bredenberg, Influence of drug distribution and solubility on release from geopolymer pellets—A finite element method study. Journal of Pharmaceutical Sciences, 101(5), 1803 (2012); https://doi.org/10.1002/jps.23071.
C. Gao, et al., Bone biomaterials. and interactions with stem cells. Bone research, 5(1), 1 (2017); https://doi.org/10.1038/boneres.2017.59.
H. Qu, et al., Biomaterials for bone tissue engineering scaffolds: A review. RSC advances, 9(45), 26252 (2019); https://doi.org/10.1039%2Fc9ra05214c.
J. Hum, and A.R. Boccaccini, Collagen as coating material for 45S5 bioactive glass-based scaffolds for bone tissue engineering. International journal of molecular sciences, 19(6), 1807 (2018); https://doi.org/10.3390%2Fijms19061807.
R. Aversa, et al., Biomechanically Tunable Nano-Silica/P-HEMA Structural Hydrogels for Bone Scaffolding. Bioengineering, 8(4), 45 (2021); https://doi.org/10.3390/bioengineering8040045.
L. Wang, et al., Bioresorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-Hydroxybutyrate. Applied Sciences, 11(12), 5627 (2021); https://doi.org/10.3390/app11125627.
R. Aversa, et al., Biomimetic and evolutionary design driven innovation in sustainable products development. American Journal of Engineering and Applied Sciences, 9(4), 1027 (2016); https://doi.org/10.3844/ajeassp.2016.1027.1036.
A. Haider, et al., Advances in the scaffolds fabrication techniques using biocompatible polymers and their biomedical application: A technical and statistical review. Journal of saudi chemical society, 24(2), 186 (2020); http://dx.doi.org/10.1016/j.jscs.2020.01.002.
M. Catauro, et al., Chemical and biological characterization of geopolymers for potential application as hard tissue prostheses. Advances in science and technology, 69, 192 (2011); https://doi.org/10.4028/www.scientific.net/AST.69.192.
E. Febrina, et al., Properties of nanocellulose and zirconia alumina on polymethylmethacrylate dental composite. Dental Journal, 56(1), 30 (2023); http://dx.doi.org/10.20473/j.djmkg.v56.i1.p30-35.
D. Sutanto, et al., Geopolymer–carbonated apatite nanocomposites with magnesium and strontium trace elements for dental restorative materials. Journal of the Korean Ceramic Society, 57(5), 546 (2020); https://doi.org/10.1007/s43207-020-00060-x.
B. Sunendar, et al. The effect of CHA-doped Sr addition to the mechanical strength of metakaolin dental implant geopolymer composite. in AIP Conference Proceedings. AIP Publishing LLC. (2017); https://doi.org/10.1063/1.5003503.
M. Refaat, et al., Utilization of optimized microwave sintering to produce safe and sustainable one-part alkali-activated materials. Scientific Reports, 13(1), 4611 (2023); https://doi.org/10.1038/s41598-023-31581-0.
D. Sutanto, et al., In vivo histomorphological evaluation of geopolymer-carbonated apatite nanocomposites implanted on rabbit tibia at early bone healing. Padjajaran Journal of Dentistry, 33(1), 64 (2021); http://dx.doi.org/10.24198/pjd.vol33no1.28899.
G. Dal Poggetto, et al., Efficient Addition of Waste Glass in MK-Based Geopolymers: Microstructure, Antibacterial and Cytotoxicity Investigation. Polymers (Basel), 13(9), 1493 (2021); https://doi.org/10.3390/polym13091493.
M. Catauro, I. Lancellotti, and C. Leonelli, Addition of WEEE Glass to Metakaolin-Based Geopolymeric Binder: A Cytotoxicity Study. Environments, 4(4), 89 (2017); https://doi.org/10.3390/environments4040089.
K.N. Katare, N.K. Samaiya, and Y. IyerMurthy, Strength and durability properties of concrete using incinerated biomedical waste ash. Environmental Engineering Research, 28(2), 220024-0 (2023); https://doi.org/10.4491/eer.2022.024.
V. Gautam, R. Thapar, and M. Sharma, Biomedical waste management: Incineration vs. environmental safety. Indian Journal of Medical Microbiology, 28(3), 191 (2010); https://doi.org/10.4103/0255-0857.66465.
K. Anastasiadou, et al., Solidification/stabilization of fly and bottom ash from medical waste incineration facility. Journal of Hazardous Materials, 207-208, 165 (2012); https://doi.org/10.1016/j.jhazmat.2011.05.027.
S. Jaber, et al., The environmental situation of the ash medical waste in Baghdad city, Iraq. E3S Web Conf.,. 286, 02017 (2021); https://doi.org/10.1051/e3sconf/202128602017.
S.K. A, et al., Influence of incinerated biomedical waste ash and waste glass powder on the mechanical and flexural properties of reinforced geopolymer concrete. Australian Journal of Structural Engineering, 23(3), 254 (2022); https://doi.org/10.1080/13287982.2022.2044613.
A. Suresh Kumar, et al. Development of Environmental-Friendly Geopolymer Concrete Using Incinerated Biomedical Waste Ash. Singapore: Springer Nature Singapore. 709 (2023); https://doi.org/10.1007/978-981-19-4040-8_56.
Rishi and V. Aggarwal, Experimental investigation of geopolymer concrete along with biomedical and bone China waste at different molarities of sodium hydroxide. Multiscale and Multidisciplinary Modeling, Experiments and Design, 6, 277 (2023); https://doi.org/10.1007/s41939-023-00147-y.
J.K. Debrah, and M.A.P. Dinis, Chemical characteristics of bottom ash from biomedical waste incinerators in Ghana. Environmental Monitoring and Assessment, 195(5): p. 568 (2023); https://doi.org/10.1007/s10661-023-11132-w.
M.C. Nataraja, et al., Self-compacting concrete incorporating incinerated biomedical waste ash: a performance assessment. Journal of Engineering and Applied Science, 70(1), 22 (2023); https://doi.org/10.1186/s44147-023-00191-y.
A.S. Kumar, et al., Improving the Performance of Structural Members by Incorporating Incinerated Bio-Medical Waste Ash in Reinforced Geopolymer Concrete. Materials Science Forum, 1048, 321 (2022); https://doi.org/10.4028/www.scientific.net/MSF.1048.321.
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